29 November 2021

Psilocybin vs escitalopram for depression

Clinical Mental Health

Dr David Lim and Professor David Nutt discuss the growing interest in the use of psychedelic agents.


  • A recent study Prof David Nutt was involved in pitted psilocybin against escitalopram in a cleverly designed equipoise randomised controlled trial
  • Results showed very rapid improvement (days rather than weeks) of depression symptoms and significantly better scores in wellbeing and depression in patients given psilocybin
  • Whilst it is clear more studies are needed, there is growing interest in the use of psychedelic agents in the treatment of depression amongst younger and trainee psychiatrists, psychotherapists, and the general public
  • As GPs, we should be aware of developments in this area

Host: Dr David Lim, GP and medical educator

Guest: Professor David Nutt, neuropsychopharmacologist; Director of the Neuropsychopharmacology Unit; Division of Brain Sciences; Imperial College, London

Total time: 32 mins

COVID-19 live update