Around 2% of women with premature ovarian insufficiency have a pre-mutation for Fragile X
Around 2% of women with premature ovarian insufficiency have a pre-mutation for Fragile X.
The pre-mutations of the FMR1 gene affect about 1 in 150 women, says Professor Rod Baber, a gynaecologist and obstetrician at The University of Sydney.
Around 25% of women with these pre-mutations will go through premature ovarian insufficiency, he says.
All women who have an early menopause should be screened for the FMR1 gene pre-mutations.
“And if they have it, they can seek appropriate genetic counselling about how to avoid having a child born with the same genetic abnormality,” says Professor Baber.
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