16 August 2018

Take 10: What effect do DDP 4 inhibitors have on heart disease?

Clinical Diabetes Drugs

Clinical trials for type 2 diabetes have explored a number of agents for reducing cardiac risk, Professor Merin Thomas, a diabetologist from Monash University, says.

Due to the failure of previous medications to demonstrate cardiac safety in patients with type 2 diabetes, new medications for glucose lowering have to go through intensive study to show that the agents were safe in patients with cardiac disease.

New drugs for type 2 diabetes, such as DDP 4 inhibitors, have been shown to be safe in patients with cardiac disease, but have not been shown to reduce MI, stroke or cardiac death.

However, the studies are only a few years in length, and some cardiac benefit may be seen if patients take the medications for a decade or more, says Professor Thomas.

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